C. Springer et al., COMPARISON OF AIRWAY-RESISTANCE AND TOTAL RESPIRATORY SYSTEM RESISTANCE IN INFANTS, The American review of respiratory disease, 148(4), 1993, pp. 1008-1012
Airway resistance (Raw) can be measured throughout the respiratory cyc
le by whole body plethysmography. Total resistance of the respiratory
system (Rrs) can be measured from the relaxed expiration that follows
end inspiratory occlusion. The purpose of this study was to compare th
e two methods in normal infants and in infants with airway obstruction
of different types and severity. Fifteen infants with essentially nor
mal lungs aged 24.6 +/- 18.0 (SD) wk, nine infants with congenital str
idor aged 36.0 +/- 17.3 wk, and eleven wheezy infants aged 20.1 +/- 11
.3 wk had simultaneous measurements of Raw and Rrs. Rrs was similar to
Raw both during inspiration and expiration in the normal infants, to
all expiratory Raw in those with congenital stridor, and to all inspir
atory and early expiratory Raw in the wheezy-infants. Raw was markedly
and significantly higher than Rrs during mid and late inspiration in
infants with congenital stridor and during late expiration in the whee
zy infants. We conclude that Rrs is a good estimate of Raw in normal i
nfants and of early expiratory Raw in all infants. In infants with air
way obstruction, Rrs does not reveal the dynamic changes in Raw during
tidal breathing, nor can it differentiate between infants with upper
and lower airway obstruction.