RESTORATION OF CORONARY BLOOD-FLOW BY SINGLE BOLUS INJECTION OF THE GPIIB IIIA RECEPTOR ANTAGONIST C7E3 FAB IN A PATIENT WITH ACUTE MYOCARDIAL-INFARCTION OF RECENT-ONSET/

It has been debated that primary coronary angioplasty could be more ef fective if immediate antithrombotic therapy would contribute to a fast er recanalization of the infarct-related artery. This is the first rep ort of a patient who presented at the emergency department with acute anterolateral myocardial infarction, in whom a single bolus injection of c7E3 Fab (0.25 mg/kg body weight) led to complete reperfusion of th e infarct-related coronary artery during organization time for planned acute coronary angioplasty. Pain relief 15 min after initiation of th erapy and ST-segment resolution of >50%, as well as occurrence of idio ventricular rhythm 30 min thereafter, were suggestive of successful re canalization before the coronary intervention was started. Diagnostic coronary angiography at 90 min revealed TIMI-grade 3 flow in the infar ct-related coronary artery with only moderate luminal irregularities. BoIus administration of c7E3 Fab could be effective for dissolving pla telet-rich thrombi in the early stage of acute myocardial infarction ( AMI) and may therefore represent a promising ''bridging'' therapy in p atients with AMI elected for primary coronary angioplasty.