LC - CLINICAL SYNDROME IN DIFFERENT PRIMARIES

Leptomeningeal carcinomatosis (LC) occurs in solid tumors like breast, lung carcinoma and melanoma, rarely sarcoma and in leukemia and lymph oma. Clinical symptoms of LC often present with differentialdiagnostic problems. The most common presentation are multiple neuraxis syndrome s which for didactic reasons are classically considered as central ner vous system (CNS), spinal (SP) or cranial nerve (CN) symptoms and sign s and appear isolated or more frequently in combinations. It is genera lly agreed that signs are usually more prominent than symptoms. Only f ew series focus on monolocular presentation at clinical manifestation. This overview describes the clinical symptoms and signs in patients w ith LC, the concept of multiple neuraxis lesions, CNS, CIN and SP sign s and symptoms. Also the problem of new symptoms and signs in patients treated with antineoplastic chemotherapy and radiation is adressed. T he study is based on own results and a survey of the present literatur e.