IN-SITU HYBRIDIZATION - A POSSIBLE DIAGNOSTIC-AID IN LEPTOMENINGEAL METASTASIS

Authors
VANOOSTENBRUGGE RJ HOPMAN AHN RAMAEKERS FCS TWIJNSTRA A
Citation
Rj. Vanoostenbrugge et al., IN-SITU HYBRIDIZATION - A POSSIBLE DIAGNOSTIC-AID IN LEPTOMENINGEAL METASTASIS, Journal of neuro-oncology, 38(2-3), 1998, pp. 127-133
Citations number
60
Categorie Soggetti
Clinical Neurology",Oncology
Journal title
Journal of neuro-oncology → ACNP
ISSN journal
0167594X
Volume
38
Issue
2-3
Year of publication
1998
Pages
127 - 133
Database
ISI
SICI code
0167-594X(1998)38:2-3<127:IH-APD>2.0.ZU;2-6
Abstract
In this review we discuss the clinical features and pathophysiology of leptomeningeal metastasis (LM), and elaborate on diagnostic tools for the detection of this serious complication of cancer. Because of the low sensitivity of the cytologic examination, new diagnostic approache s have been developed. The in situ hybridization technique may prove t o be a reliable and early test for the detection of LM.