Three full term newborns with focal ischemic injury of the middle cere
bral artery (MCA) were observed. Diagnosis was suspected by cerebral u
ltrasonography (US) in the first year of life and then was confirmed b
y CT-scan and/or MRI. rill children had a history of pre-perinatal ris
k factors of fetal impairment. Neuropsychological outcome, ranging fro
m normal to severe, was evaluated in all three patients; it appears to
be related to the type and extension of cerebral injury. In full-term
neonates.with discrete, moderate or severe neurologic symptoms the po
ssibility of focal ischemic injury in the R-ICA territory should be co
nsidered.