TUMOR LYSIS SYNDROME - AN UNCOMMON COMPLICATION OF FLUDARABINE THERAPY OF CHRONIC LYMPHOCYTIC-LEUKEMIA

Purpose: To quantify the incidence and severity of tumor lysis syndrom e (TLS) as a consequence of fludarabine therapy in patients with advan ced chronic lymphocytic leukemia (CLL). Patients and Methods: A retros pective review and questionnaire follow-up of clinical and laboratory data were performed on patients with intermediate or highrisk CLL on t he National Cancer institute Group C protocol or special exception mec hanisms, or phase II trials of fludarabine, for whom adverse drug repo rts of TLS were available. Fludarabine was administered at a dose of 2 0 to 40 mg/m(2) per day for 5 days at monthly intervals. Results: Amon g the 6,137 patients, TLS was suspected in 26 (0.42%), with clinical a nd laboratory features consistent with TLS present in 20 (0.33%). Prop hylaxis against TLS had been administered to 60% of these patients. Cl inical or laboratory features were similar to patients who did not dev elop TLS. Of the patients with TLS, 90% herd high-risk CLL, 60 months of prior disease duration, with a median pretreatment WBC of 109 x 10( 9)/L, two prior regimens, lymphadenapathy in 89%, splenomegaly and/or hepatomegaly in 90%. TLS developed on approximately day 7 and lasted a median of 9.5 days. Dialysis was required in 30% during the TLS episo de; 20% of patients died during cycle one of fludarabine therapy with renal failure, and another 20% died of infection or congestive heart f ailure. Six patients were retreated with fludarabine without recurrent TLS,Conclusion: TLS after fludarabine therapy is extremely uncommon, but may be associated with significant morbidity and mortality.