QUANTITATIVE-DETERMINATION OF BUCINDOLOL CONCENTRATION IN INTACT GEL CAPSULES USING RAMAN-SPECTROSCOPY

The ideal quality control method for pharmaceutical products should be capable of rapid nondestructive testing of intact tablets or capsules . Raman spectroscopy using near-infrared excitation is shown to be cap able of obtaining useful spectral data directly from drug formulations in gel capsules and from the gel capsules inside blister packs. The R aman data collected from the capsules inside blister packs containing 0-100 mg of the active ingredient (bucindolol), when coupled with mult ivariate calibration, resulted in a calibration SEP of 3.36 mg. The la rgest source of error was found to be due to sample inhomogeneity. Eve n so, the method is shown to have significant potential as a rapid non destructive quality control method for pharmaceutical samples.