MYELODYSPLASTIC SYNDROME AFTER REGRESSION OF TRANSIENT ABNORMAL MYELOPOIESIS IN A DOWN-SYNDROME INFANT - DIFFERENT CLONAL ORIGIN

Authors
KOUNAMI S AOYAGI N TSUNO H SUZUKI H KOBAYASHI M KOIKE M
Citation
S. Kounami et al., MYELODYSPLASTIC SYNDROME AFTER REGRESSION OF TRANSIENT ABNORMAL MYELOPOIESIS IN A DOWN-SYNDROME INFANT - DIFFERENT CLONAL ORIGIN, Cancer genetics and cytogenetics, 104(2), 1998, pp. 115-118
Citations number
14
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
104
Issue
2
Year of publication
1998
Pages
115 - 118
Database
ISI
SICI code
0165-4608(1998)104:2<115:MSAROT>2.0.ZU;2-X
Abstract
A boy with Down syndrome who developed myelodysplastic syndrome after regression of transient abnormal myelopoiesis (TAM) is described. His blast cells in TAM had other chromosome abnormalities in addition to t risomy 21;50,XY, +21c, +12, +14, +21. Serial chromosome analysis in fo llow-up showed abnormal clones involving monosomy 7. Myelodysplastic s yndrome was diagnosed. Because two clones had different karyotypes, th ey might have derived from different clones. (C) Elsevier Science Inc. , 1998.