HIGHLY COMPLEX CHROMOSOMAL REARRANGEMENT OF CHROMOSOME-9 IN A CASE OFCHRONIC MYELOID-LEUKEMIA

Authors
LAU LC KNIGHT L TIEN SL LIM P YONG MH CHONG YY
Citation
Lc. Lau et al., HIGHLY COMPLEX CHROMOSOMAL REARRANGEMENT OF CHROMOSOME-9 IN A CASE OFCHRONIC MYELOID-LEUKEMIA, Cancer genetics and cytogenetics, 104(2), 1998, pp. 153-156
Citations number
10
Categorie Soggetti
Oncology,"Genetics & Heredity
Journal title
Cancer genetics and cytogenetics → ACNP
ISSN journal
01654608
Volume
104
Issue
2
Year of publication
1998
Pages
153 - 156
Database
ISI
SICI code
0165-4608(1998)104:2<153:HCCROC>2.0.ZU;2-E
Abstract
A 63-year-old man with chronic myeloid leukemia (CML) was found to hav e a new complex Philadelphia translocation. All of the bone marrow cel ls had a rearrangement of a five-way translocation, t(9;22;10;12;1), i nvolving a single chromosome 9. The patient went into blast crisis two years after initial diagnosis and the karyotype remained unchanged. H e died in blast crisis 10 months later. We believe this case is a uniq ue 5-way translocation in which four chromosomes were translocated to a single chromosome. (C) Elsevier Science Inc., 1998.