DRUG-DELIVERY BY INHALATION OF CHARGED-PARTICLES

All solid and liquid particles produced naturally or by energetic indu strial processes are electrically charged. Although the natural levels of charge are normally insufficient to influence the deposition of in haled particles in the lung it is possible to increase charge levels s o that a significant increase in lung deposition is caused. By careful control of breathing, particle size and charge it is possible io targ et specific regions of the lung. Predictions Of targeted deposition us ing the Southampton lung model are presented and a brief description o f complementary clinical studies is given.