PUBLICATION BIAS AND RESEARCH ON PASSIVE SMOKING - COMPARISON OF PUBLISHED AND UNPUBLISHED STUDIES

Context.-The results of reviews may be biased by delays in publication and failure to publish nonsignificant results. Objective.-To determin e the extent of unpublished results on the health effects of passive s moking and whether passive smoking studies with statistically nonsigni ficant results would have longer time to publication than those with s tatistically significant results. Design.-Semistructured telephone int erviews of principal investigators of published or unpublished studies funded between 1981 and 1995, identified by information obtained from 76 (85%) of 89 organizations contacted that potentially funded resear ch on passive smoking. Participants.-Seventy-eight investigators were eligible and could be located; 65 (83%) responded. They had conducted 61 studies of the health effects of passive smoke in humans or animals between 1981 and 1995 that met the criteria for the analysis of time to publication. Main Outcome Measure.-Time to publication for publishe d studies and statistical significance of results of published and unp ublished studies. Results.-Fourteen of the 61 studies were unpublished . Median time to publication was 5 years (95% confidence interval [CI] , 4-7 years) for statistically nonsignificant studies and 3 years (95% CI, 3-5 years) for statistically significant studies (P=.004). Statis tically significant results (P=.004), experimental study design (P=.01 ), study size less than or equal to 500 (P=.01), and animals as subjec ts (P=.03) were predictive of time to publication. When the studies wi th human participants were analyzed separately, only statistically sig nificant data were predictive of publication (P=.007). Multivariate an alysis of all studies indicated that statistical significance (P=.001) and study design (P=.01) were the only independent predictors of time to publication, while for the human studies only statistical signific ance was predictive of publication (P=.007). Conclusion.-There is a pu blication delay for passive smoking studies with nonsignificant result s compared with those with significant results.