Bone lesions in African histoplasmosis caused by Histoplasma capsulatu
m var. duboisii, without other signs of the infection, are often misdi
agnosed as cancer. A case of isolated osteomyelitis due to this fungus
in a 30-year-old woman is described. Diagnostic and therapeutic probl
ems of isolated bone lesions in African histoplasmosis are discussed.
A high diagnostic index of African histoplasmosis is advocated in isol
ated bone lesions in the endemic region of this disease.