A DISPERSION MODEL FOR THE HEPATIC-UPTAKE AND ELIMINATION OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN

Authors
BANKS HT MUSANTE CJ TRAN HT
Citation
Ht. Banks et al., A DISPERSION MODEL FOR THE HEPATIC-UPTAKE AND ELIMINATION OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN, Mathematical and computer modelling, 28(1), 1998, pp. 9-29
Citations number
36
Categorie Soggetti
Mathematics,"Computer Science Interdisciplinary Applications","Computer Science Software Graphycs Programming",Mathematics,"Computer Science Interdisciplinary Applications","Computer Science Software Graphycs Programming
Journal title
Mathematical and computer modelling → ACNP
ISSN journal
08957177
Volume
28
Issue
1
Year of publication
1998
Pages
9 - 29
Database
ISI
SICI code
0895-7177(1998)28:1<9:ADMFTH>2.0.ZU;2-J
Abstract
A convection-dispersion model for the uptake and elimination of 2,3,7, 8-tetrachlorodibenzo-p-dioxin (TCDD) in the liver is presented. The mo del is adapted from the general dispersion model of Roberts and Rowlan d and includes the dynamics of TCDD interaction with two intracellular proteins, the Ah receptor and cytochrome P450 IA2. A ''well-mixed'' c ompartment was added to describe the venous blood concentration of TCD D. The result is a nonlinear system of seven coupled partial and ordin ary differential equations with time delays. (C) 1998 Elsevier Science Ltd. All rights reserved.