SYNTHESIS, ANTIMICROBIAL AND CYTOSTATIC ACTIVITIES OF SOME DERIVATIVES OF INDOLO[2,3-B]-1,5-BENZOTHIAZEPINE, A NOVEL HETEROCYCLIC RING-SYSTEM

Authors
AMBROGI V FURLANI A GRANDOLINI G PAPAIOANNOU A PERIOLI L SCARCIA V TUTTOBELLO L
Citation
V. Ambrogi et al., SYNTHESIS, ANTIMICROBIAL AND CYTOSTATIC ACTIVITIES OF SOME DERIVATIVES OF INDOLO[2,3-B]-1,5-BENZOTHIAZEPINE, A NOVEL HETEROCYCLIC RING-SYSTEM, European journal of medicinal chemistry, 28(9), 1993, pp. 659-667
Citations number
12
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
28
Issue
9
Year of publication
1993
Pages
659 - 667
Database
ISI
SICI code
0223-5234(1993)28:9<659:SAACAO>2.0.ZU;2-T
Abstract
Some derivatives of indolo[2,3-b]-1,5-benzothiazepine, a novel heteroc yclic ring system, and of its 5,6-dihydroderivative have been obtained by Fischer indolization of corresponding phenylhydrazones. All the te tracyclic compounds were studied for their antimicrobial and cytostati c activities and several of them showed good activity against Gram-pos itive bacteria and Cryptococci.