RADIOPROTECTIVE EFFECT OF LOW-DOSES OF 2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE ALONE OR ASSOCIATED WITH PHOSPHOROTHIOATES

Authors
LAVAL JD ROMAN V LADURANTY J MIGINIAC L LION C SENTENACROUMANOU H FATOME M
Citation
Jd. Laval et al., RADIOPROTECTIVE EFFECT OF LOW-DOSES OF 2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE ALONE OR ASSOCIATED WITH PHOSPHOROTHIOATES, European journal of medicinal chemistry, 28(9), 1993, pp. 709-713
Citations number
18
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
28
Issue
9
Year of publication
1993
Pages
709 - 713
Database
ISI
SICI code
0223-5234(1993)28:9<709:REOLO2>2.0.ZU;2-6
Abstract
In the mouse, the intraperitoneal injection of 2-(1-naphthylmethyl)-2- imidazoline has a radioprotective effect even at low doses. Its associ ation with S-[2-(3-aminopropyl)aminoethyl] phosphorothioate (WR 2721) or 3-methylaminopropyl)-amino-propyl]phosphorothioate (WR 151327) at l ow doses led to an enhancement of their respective radioprotective act ivities without any apparent side effects. These results strengthen th e interest of this non-sulphur compound as a radioprotector.