STUDY OF ELECTRON-DONOR ACCEPTOR COMPLEXES IN THE GROUP OF LOCAL-ANESTHETICS - THE USE OF EQUILIBRIUM CONSTANTS-K(C) IN QSAR STUDY

The formation of electron donor-acceptor complexes (CT complexes) was studied by electron spectroscopy. A number of hydrochlorides of substi tuted phenylcarbamic acid basic esters with a marked local anesthetic activity were used as electron donors. Chloranil was used as the elect ron acceptor. The local anesthetics used in practice, cinchocaine hydr ochloride, tetracaine hydrochloride and trimecaine hydrochloride, were used for comparison. The equilibrium constants K(c) were determined u sing the Benesi-Hildebrand method and as a parameter in QSAR equations .