P. Barrau et al., DELAYED POSTANESTHETIC RECOVERY FROM A PO SSIBLE INTERACTION BETWEEN MIDAZOLAM AND FAMOTIDINE, Annales francaises d'anesthesie et de reanimation, 17(5), 1998, pp. 361-364
We report the case of a 79-year-old woman, in chronic renal insufficie
ncy who recovered from anaesthesia after a delay of 24 hours, after fl
umazenil (Anexate(R)) administration. She was given famotidine (Pepdin
e(R)) the day before surgery. Midazolam was administered for premedica
tion (5 mg per os) and for the induction of anaesthesia (2 mg intraven
ous). Among the various causes of delayed recovery in this elderly pat
ient, an interaction between midazolam and famotidine is discussed. (C
) 1998 Elsevier, Paris.