Mohs micrographic surgery (MMS) is a specialized type of minimal margi
nal surgery that offers cure rates superior to other options in the tr
eatment of contiguous skin cancers in selected settings. Developed by
Dr. Frederic E. Mohs, the technique originally required in situ tissue
fixation before excision. Most Mohs micrographic surgeons now use the
fresh tissue technique exclusively. Horizontal frozen histologic sect
ions of the excised tumor permit more complete microscopic examination
of the surgical margin than traditional methods. Residual tumor is gr
aphically mapped and malignant extensions are pursued with staged exci
sions until the tumor is removed. Maximum sparing of tumor-free adjace
nt tissue is achieved with histologic mapping of the tumor boundaries,
thus optimizing subsequent wound reconstruction. The history, techniq
ues, indications, cure rates, and current controversies of MMS are rev
iewed.