ORGANOTIN COMPLEXES WITH PYRROLE-2,5-DICARBOXALDEHYDE BIS(ACYLHYDRAZONES) - SYNTHESIS, STRUCTURE, ANTIMICROBIAL ACTIVITY AND GENOTOXICITY

Mono- and bimetallic organotin complexes with pyrrole-2,5-dicarboxalde hyde bis(2-hydroxybenzoylhydrazone) (H(5)dfps) and pyrrole-2,5-dicarbo xaldehyde bis(2-picolinoylhydrazone) (H(3)dfpp) were synthesized and c haracterized by IR, H-1 and Sn-119 NMR spectroscopy. X-ray analysis of the complex [Sn(H(3)dfpS)(C6H5)(2)].(CH3)(2)SO revealed a pentacoordi nation around tin through a N,N,O terdentate ligand behaviour of the h ydrazone. This complex is the most active compound, exhibiting MIC val ues of 3 and 12 mu g/ml against Gram positive and Gram negative bacter ia, respectively. None of the ligands or complexes produced DNA-damage in the Bacillus subtilis rec-assay or showed mutagenic activity in th e Salmonella-microsome test. (C) 1998 Elsevier Science Inc. All rights reserved.