CYANONITROSYLMETALLATES AS POTENTIAL NO-DONORS

The [M(CN)(x)NOy](n-) complexes (where M = Cr(I), Mn(I), Mn(II), Fe(I) , Fe(II), Fe(III)) were studied as potential NO-donors using both phar macological and theoretical semi-empirical methods. Only iron complexe s appeared to be pharmacologically active. The quantum chemical calcul ations indicated that these complexes have the highest predisposition to undergo a nucleophilic attack followed by the NO+ release. The resu lts allowed us to interpret the metabolism of the [M(CN)(x)NOy](n-) co mplexes in terms of the NO+-donation. (C) 1998 Elsevier Science Inc. A ll rights reserved.