Next to bacteria microbial hazards in food comprise mycotoxin-producin
g moulds, protozoae, viruses and prions. Epidemiological aspects are m
entioned which are essential for the pathogenesis of foodborne disease
s caused by these agents. Compared with chemical and physical hazards
the occurrence or emergence of microbiological hazards depends on a va
riety of factors and influences during food production and processing
that well structured hygiene and food safety management concepts respe
ctively are essential. In particular this paper refers to the minimal
infective dose for man, the factors influencing growth of bacteria in
food and to predictive microbiology. The application of the hazard ana
lysis critical control point (HACCP) concept for microbial hazards is
mentioned with particular emphasis on the importance of monitoring. Du
e to the particular significance of the faeco-oral transmission route
for many bacterial foodborne diseases basic hygiene measures assume a
decisive importance in food safety management. The HACCP system is bas
ed upon such measures and should only be viewed as part of an efficien
t total hygiene concept in food companies. The example of drinking mil
k pasteurization illustrates that the introduction of the HACCP system
does not constitute a fundamentally new development and that it shoul
d rather be viewed as a renaissance of old principles of natural scien
ce and hygiene. (C) 1998 Elsevier Science Ltd. All rights reserved.