THEORY AND METHODOLOGY OF ANTIBIOTIC EXTRACTION FROM BIOMATRICES

A short review on the basic theory and practices of the extraction and clean-up of agricultural antibiotics from biomatrices is presented. F or the analysis of residues of ionophores, beta-lactams, macrolides, c hloramphenicol, aminoglycosides, tetracyclines and peptide antibiotics , the use of solid-phase extraction has become nearly ubiquitous as pa rt of the basic extraction methodology. The majority of the methodolog ies for these compounds report recoveries greater than 70%, with relat ive standard deviations usually less than 15%. Each of the antibiotic classes, as well as antibiotics within each class, have unique chemist ries that must be taken into account when developing a viable extracti on method. (C) 1998 Elsevier Science B.V. All rights reserved.