Mi. Papisov, THEORETICAL CONSIDERATIONS OF RES-AVOIDING LIPOSOMES - MOLECULAR MECHANICS AND CHEMISTRY OF LIPOSOME INTERACTIONS, Advanced drug delivery reviews, 32(1-2), 1998, pp. 119-138
The development of long-circulating, RES-avoiding liposomes has become
a remarkable milestone in the progress of contemporary pharmacology.
Drugs incorporated in such liposomes are protected from fast metaboliz
ation and clearance, and can be further targeted to a desired tissue s
ite. Ideally, future developments should result in drug carriers which
can identify and act upon their targets with even higher efficiency a
nd selectivity, preferably close to or exceeding that of the natural i
mmune cells. Further increasing carrier 'inertness' with regard to the
normal biological milieu is the major requirement for future success.
The ability of natural blood components to circulate with blood for s
everal days and weeks presents both the motivation and the challenge f
or further research. Today, even the best available preparations are i
nferior to natural proteins and cells with regard to their ability to
remain in circulation by approximately two orders of magnitude. In vie
w of the above, it seems vitally important to determine the mechanisms
responsible for glycolipid- or polymer-modified liposome protection a
gainst RES, and whether any potentially useful mechanisms have been un
derutilized. Furthermore, identification of quantitative dependencies
between liposome structure and pharmacokinetics (and mechanisms underl
ying such dependencies) would benefit future research and reduce the c
ost of development. This paper discusses the relationships between lip
osome structure and circulation with respect to the theoretical mechan
istic models of mass transfer, liposome interactions with cells and bl
ood proteins, and boundary effects resulting from surface modification
. Special attention is paid to the practical application and limitatio
ns of the models. (C) 1998 Elsevier Science B.V.