RASHES AFTER PYRAZINAMIDE TREATMENT

We report 3 cases of rash after the first dose of antituberculosis pol ytherapy, thus raising questions concerning the procedures to be follo wed. Case report, Three patients developed a pruritic rash I hour afte r rite first dose of isoniazide, rifampicine, pyrazinamide and ethambu tol given simultaneously,. The eruption did not recur after readminist ration of isoniazide and rifampicine successively. Pyrazinamide, which was readministered ed last (at the full dose in one case and at progr essive doses in the two others), induced a recurrence in two of them, Pyrazinamide was definitively with-drawn in one patient with recurrenc e and slower pyrazinamide readministration allowed continuation of tre atment in the other two patients. Conclusion. Since pyrazinamide appea led to be responsible for rash following the first administration of a ntituberculosis polytherapy, a protocol for readministration of the 4 drugs is suggested, IS the responsibility of pyrazinamide is confirmed it should be readministered very slowly.