HIGH POTASSIUM-INDUCED GLUTAMATE RELEASE IN THE COCHLEA - IN-VIVO MICRODIALYSIS STUDY COMBINED WITH ONLINE ENZYME FLUOROMETRIC DETECTION OFGLUTAMATE

Authors
MATSUDA K UEDA Y HARUTA A TONO T KOMUNE S
Citation
K. Matsuda et al., HIGH POTASSIUM-INDUCED GLUTAMATE RELEASE IN THE COCHLEA - IN-VIVO MICRODIALYSIS STUDY COMBINED WITH ONLINE ENZYME FLUOROMETRIC DETECTION OFGLUTAMATE, Brain research, 794(2), 1998, pp. 343-346
Citations number
21
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
794
Issue
2
Year of publication
1998
Pages
343 - 346
Database
ISI
SICI code
0006-8993(1998)794:2<343:HPGRIT>2.0.ZU;2-G
Abstract
The time course of changes in perilymphatic glutamate release and thei r Ca2+-dependency were studied in the guinea pig cochlea during high K +-evoked depolarization. The glutamate concentration was analyzed cont inuously by an enzyme-linked fluorometric assay combined with microdia lysis. Two peaks of glutamate increase were found in response to perfu sion for 10 min. In the absence of Ca2+ the first peak was diminished, whereas the inhibition of the second peak was minimal. (C) 1998 Elsev ier Science B.V. All rights reserved.