BINDING ABILITY OF IMPROMIDINE, A POTENT H-2 HISTAMINE AGONIST AND ITS ANALOGS

Authors
MOREEUW AM DECOCK P TIMMERMAN H KOZLOWSKI H
Citation
Am. Moreeuw et al., BINDING ABILITY OF IMPROMIDINE, A POTENT H-2 HISTAMINE AGONIST AND ITS ANALOGS, Journal of inorganic biochemistry, 70(2), 1998, pp. 107-111
Citations number
13
Categorie Soggetti
Biology,"Chemistry Inorganic & Nuclear
Journal title
Journal of inorganic biochemistry → ACNP
ISSN journal
01620134
Volume
70
Issue
2
Year of publication
1998
Pages
107 - 111
Database
ISI
SICI code
0162-0134(1998)70:2<107:BAOIAP>2.0.ZU;2-#
Abstract
Potentiometric and spectroscopic (UV-VIS, EPR) methods were used to es tablish the co-ordination equilibria in Cu2+-impromidine solutions. Im promidine, a strong H-2 histamine agonist, was found to be an effectiv e ligand co-ordinating to the Cu2+ ion via two imidazole rings with th e formation of a 15-membered macrochelate. CuL and CuL2 are the major complexes formed, with a bis-complex dominating at physiological pH. ( C) 1998 Elsevier Science Inc. All rights reserved.