SYNTHESIS, CHARACTERIZATION, AND RADICAL SCAVENGING EFFECTS OF POLYNUCLEAR THIOLATE COMPLEXES

Three thiolate complexes (Me4N)(2)[M-4(o-SC6H4CH3)(10)], [M = Zn (1); Cd (2)] and [c-mu(4)-S)(SCH2Ph)(12)S4Zn8] (3) were synthesized and cha racterized by elemental analyses, IR, and H-1 NMR Spectroscopic techni ques. The suppression abilities of complexes for the hydroxyl radical (OH .) and TEMP (HO-N-O .) were determined by EPR. The former were als o measured by its reaction with 3-methylthiobutyraldehyde (MBA) to giv e propylene and methane analyzed by GC. The results show that the comp lexes possess selectively scavenging effects: on the hydroxyl radicals , abilities decreased across the series 3 > NMT > 2 approximate to 1 ( NMT = native metallothionein), whereas, on TEMP radicals, the order wa s 1 > 3 > NMT > 2. (C) 1998 Elsevier Science Inc. All rights reserved.