Epilepsy is the most prevalent chronic neurologic condition. in develo
ped countries, its incidence is 30-50 per 100 000 population per year
and the prevalence is approximately 5-8 cases per 1 000 population. Th
e rapid growth of health care expenditures has led to increased intere
st in economic evaluation of health care programs. We reviewed studies
on the costs of epilepsy to assess the significance of their quantita
tive results, through a specific scheme of analysis. The main findings
of our study are that a general consensus on cost of illness evaluati
on is still remote and many studies lack technical details, making dif
ficult any useful comparison of results. New efforts should be realize
d to achieve a major degree of standardization in methodological proce
sses.