DIRECT GAS-CHROMATOGRAPHIC SEPARATION OF DRUG RACEMATES

Authors
SCHLEUDER M DURRBECK A JIRA T
Citation
M. Schleuder et al., DIRECT GAS-CHROMATOGRAPHIC SEPARATION OF DRUG RACEMATES, Die Pharmazie, 53(6), 1998, pp. 381-386
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
53
Issue
6
Year of publication
1998
Pages
381 - 386
Database
ISI
SICI code
0031-7144(1998)53:6<381:DGSODR>2.0.ZU;2-N
Abstract
For inspection of the direct separability of synthetic drug racemates through GC/MS a uniform scheme is proposed and checked with 35 drugs a nd two cyclodextrin capillary columns. All investigated analytes vapor ized without decomposition, 26 of them are separable in the enantiomer s, among them 10 with separation to the baseline and 14 with CO-NH-str ucture.