EVALUATION OF SOME 2-SUBSTITUTED DERIVATIVES OF XANTHONE FOR ANTICONVULSANT PROPERTIES

A series of alkanolamides and alkanoamines derivatives of xanthone wer e prepared and evaluated for antiepileptic activity in the maximal ele ctroshock seizure (MES) and subcutaneous pentylenetetrazol seizure thr eshold (ScMet) assays and for neurotoxicity (TOX). Several analogues f rom the appropriate alkanolamines were found to be active in both the anticonvulsant tests. Most interesting were the anticonvulsant results of the appropriate 2-amino- or 2-N-methylamino-1-butanol derivatives of 7-chloroxanthone 8-11, which displayed anti-MES activity with a pro tective index (TD50/ED50) in the range 2.84-3.62 for 8-11 correspondin g with that for phenytoin, carbamazepine and valproate.