SEPARATION AND DETERMINATION OF CYCLODEXTRINS BY CAPILLARY-ELECTROPHORESIS WITH AMPEROMETRIC DETECTION

Citation
Yz. Fang et al., SEPARATION AND DETERMINATION OF CYCLODEXTRINS BY CAPILLARY-ELECTROPHORESIS WITH AMPEROMETRIC DETECTION, Analytica chimica acta, 369(1-2), 1998, pp. 39-45
Citations number
31
Categorie Soggetti
Chemistry Analytical
Journal title
ISSN journal
00032670
Volume
369
Issue
1-2
Year of publication
1998
Pages
39 - 45
Database
ISI
SICI code
0003-2670(1998)369:1-2<39:SADOCB>2.0.ZU;2-Z
Abstract
A simple method allowing the efficient separation and determination of cyclodextrins (CDs) by capillary electrophoresis (CE) with amperometr ic detection was demonstrated. Three native CDs, alpha-, beta- and gam ma-CD, were baseline separated within 22 min and their detection limit s were determined to be 2.0, 1.6 and 1.0 mu M, respectively, under the optimum conditions. Mono-2-Ohydroxypropyl-beta-CD and beta-CD, which could not be baseline separated under the conditions used to separate the native CDs, were completely separated when sodium toluene-p-sulfon ate was added into the running buffer. (C) 1998 Elsevier Science B.V. All rights reserved.