BIOASSAY GUIDED ISOLATION OF A NEW C-18-POLYACETYLENE, (-9(Z),17-OCTADECADIENE-12,14-DIYNE-1,11,16-TRIOL, FROM CUSSONIA-BARTERI())

Authors
PAPAJEWSKI S GUSE JH KLAIBER I ROOS G SUSSMUTH R VOGLER B WALTER CU KRAUS W
Citation
S. Papajewski et al., BIOASSAY GUIDED ISOLATION OF A NEW C-18-POLYACETYLENE, (-9(Z),17-OCTADECADIENE-12,14-DIYNE-1,11,16-TRIOL, FROM CUSSONIA-BARTERI()), Planta medica, 64(5), 1998, pp. 479-481
Citations number
12
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences","Chemistry Medicinal
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
64
Issue
5
Year of publication
1998
Pages
479 - 481
Database
ISI
SICI code
0032-0943(1998)64:5<479:BGIOAN>2.0.ZU;2-F
Abstract
A novel C-18-polyacetylene, +)-9(Z),17-octadecadiene-12,14-diyne-1,11, 16-triol (3), has been isolated from the ethyl acetate extract of Cuss onia barteri (Araliaceae) leaves collected in Cameroon. The structure determination was achieved by NMR, mass, IR, and UV spectroscopy. The new polyenyne shows antibacterial activity against Bacillus subtilis a nd Pseudomonas fluorescens, antifungal activity against Cladosporium c ucumerinum, molluscicidal activity against Biomphalaria glabrata at lo w concentrations, and in addition it possesses haemolytic activity.