MULTIPLE INTRACEREBRAL HEMORRHAGES AND VASOSPASM FOLLOWING ANTIMIGRAINOUS DRUG-ABUSE

The occurrence of intracerebral hemorrhage during an acute attack of m igraine remains questionable. A normotensive migrainous woman experien ced multiple intracerebral hemorrhages. No drug abuse was recorded, bu t bleeding occurred after the use of several antimigrainous drugs. Ang iography revealed severe vasospasm of both anterior cerebral arteries. Subsequent brain MRI and MRI angiography failed to show any vascular abnormalities. Echocardiography and an exhaustive biological evaluatio n ruled out an alternative condition favoring intracerebral hemorrhage . Multiple intracerebral hemorrhages in migraine may exceptionally be related to vasospasm leading to arterial wall injury. Intracranial art erial vasospasm could be precipitated by excessive vasoactive therapy.