A CONTROLLED STUDY OF THE INFLUENCE OF SEGREGATION OF TUBERCULOUS PATIENTS FOR ONE-YEAR ON THE ATTACK RATE OF TUBERCULOSIS IN A 5-YEAR PERIOD IN CLOSE FAMILY CONTACTS IN SOUTH INDIA (REPRINTED FROM BULLETIN OFTHE WORLD HEALTH ORGANIZATION, VOL 34, PG 517-532, 1966)
Sr. Kamat et al., A CONTROLLED STUDY OF THE INFLUENCE OF SEGREGATION OF TUBERCULOUS PATIENTS FOR ONE-YEAR ON THE ATTACK RATE OF TUBERCULOSIS IN A 5-YEAR PERIOD IN CLOSE FAMILY CONTACTS IN SOUTH INDIA (REPRINTED FROM BULLETIN OFTHE WORLD HEALTH ORGANIZATION, VOL 34, PG 517-532, 1966), Bulletin of the World Health Organization, 76(2), 1998, pp. 109-124
This report is the last of a series of nine publications from the Tube
rculosis Chemotherapy Centre, Madras, concerning various aspects of an
investigation of the role of ambulatory chemotherapy for pulmonary tu
berculosis. It presents the attack rates of tuberculosis over a 5-year
period of follow-up of close family contacts of patients, all of whom
were treated for one year with isoniazid plus PAS, half (selected at
random) in sanatorium and half at home. The incidence of active tuberc
ulosis and of tuberculous infection was no greater in the contacts of
patients treated at home than in the contacts of patients treated in s
anatorium, either in the first year or over the subsequent four years.
The major risk to the contacts resulted from exposure to the patient
before diagnosis. These findings reaffirm that close family contacts o
f patients treated at home were at no additional risk of developing tu
berculosis, provided the patients received effective chemotherapy. Fin
ally, this study has shown that it is possible in South India to obtai
n extremely good co-operation from a group of families over a period o
f several years.