P. Johnstrom et al., SYNTHESIS OF [METHOXY-C-11]PD153035, A SELECTIVE EGF RECEPTOR TYROSINE KINASE INHIBITOR, Journal of labelled compounds & radiopharmaceuticals, 41(7), 1998, pp. 623-629
Citations number
12
Categorie Soggetti
Chemistry Analytical","Chemistry Medicinal","Biochemical Research Methods","Pharmacology & Pharmacy
[Methoxy-C-11]PD153035, a potent and specific inhibitor of the EGF rec
eptor tyrosine kinase, was prepared by O-alkylation of O-desmethyl PD1
53035 with [C-11]methyl iodide in DMF. The radiochemical incorporation
of [C-11]CH3I was on the order of 45%. The mean specific activity obt
ained at end-of-synthesis (EOS) was 26 GBq/mu mol (n = 3; range 20-36
GBq/mu mol) and total synthesis time was 45-50 minutes including formu
lation.