NONPEPTIDE FIBRINOGEN RECEPTOR ANTAGONISTS - 3 - THE SYNTHESIS OF [H-3]L-767,685 AND [H-3]L-767,679

The synthesis of the fibrinogen receptor antagonist [H-3]L-767,679 and its ethyl ester prodrug [H-3]L-767,685 is described. Bromination of a n appropriate benzolactam followed by catalytic tritiation with tritiu m gas gave a labelled benzolactam that was converted to [H-3]L-767,685 via a coupling/deprotection sequence. Hydrolysis of [H-3]L-767,685 th en gave the acid [H-3]L-767,679. These two compounds were obtained wit h a specific activity of 10-16 Ci/mmol.