SEQUENCING-BASED TYPING REVEALS 6 NOVEL MHC CLASS-I CHAIN-RELATED GENE-B (MICB) ALLELES

Authors
VISSER CJT TILANUS MGJ SCHAEFFER V TATARI Z TAMOUZA R JANIN A CHARRON D
Citation
Cjt. Visser et al., SEQUENCING-BASED TYPING REVEALS 6 NOVEL MHC CLASS-I CHAIN-RELATED GENE-B (MICB) ALLELES, Tissue antigens, 51(6), 1998, pp. 649-652
Citations number
9
Categorie Soggetti
Pathology,Immunology,"Cell Biology
Journal title
Tissue antigens → ACNP
ISSN journal
00012815
Volume
51
Issue
6
Year of publication
1998
Pages
649 - 652
Database
ISI
SICI code
0001-2815(1998)51:6<649:STR6NM>2.0.ZU;2-E
Abstract
The MHC class I chain-related gene A (MICA) is highly poly morphic, In this paper we demonstrate polymorphism in the other expressing member of the MIC family of genes: MICB. Using a sequencing-based typing app roach on cDNA, analysis of exons 2 through 6 revealed eight polymorphi c sites resulting in six unique MICB sequences. Although MICE has high nucleotide homology with MICA, its polymorphism is restricted and at different sites compared to those in MICA.