EXTRAVULVAR SUBCUTANEOUS CELLULAR ANGIOFIBROMA

Cellular angiofibroma is a rare distinctive mesenchymal neoplasm of th e vulva or perineal region. We report here one unique extravulvar case . A 43-year-old woman presented with an asymptomatic tumor, 7 cm in di ameter, located in the subcutaneous tissue of the chest below the left submammary sulcus. Histologically, the lesion was composed of uniform spindled stroma cells, numerous thick-walled vessels, and scarce matu re adipocytes. An additional feature was the presence of prominent per ivascular lymphoid aggregates. The stromal cells were positive for vim entin and negative for CD34 and muscle, epithelial, myoepithelial, or neural markers. Although nasopharyngeal angiofibroma or the group of a cral angiofibromas have a concurrent heading, cellular angiofibroma sh ould not be mistaken with them. Differential diagnosis of this distinc tive tumor especially includes aggressive angiomyxoma, angiomyofibrobl astoma, superficial angiomyxoma, vascular myxolipoma, and other tumors with spindle cells reminiscent of those in angiofibroma.