PREDICTIVE WASHING TEST FOR EVALUATION OF INDIVIDUAL ECZEMA RISK

It was the aim of our studies to estimate predictively the individual eczema risk for persons due to repetitive contact with washing-active substances, by a barrier function test on clinically healthy skin over 2 weeks. Within the scope of the study 3 groups with different atopy scores were compared. As washing solutions, 0.1 m SLS and a slightly a cid soap-free washing emulsion were used in comparison to tap water. P rior to the Ist washing procedure, on days 3, 5, 8, 10, and 12, the tr ansepidermal water loss, the horny layer moisture, and the skin blood flow were measured as parameters of barrier function, as well as the i nflammatory reaction. The results prove that the atopy score has only limited validity as a predictive method for the acceptance of washing- active substances. The repetitive washing test, however, seems to be m ore adequate for evaluating the individual barrier function as well as the eczema risk. Irritation by a washing procedure may be greatly inf luenced by choice of the washing solution. (C) Munksgaard, 1998.