INHIBITION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE BY BIOFLAVONOIDS AND THEIR INTERACTION WITH FUROSEMIDE AND GOSSYPOL

Authors
GUO J REIDENBERG MM
Citation
J. Guo et Mm. Reidenberg, INHIBITION OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE BY BIOFLAVONOIDS AND THEIR INTERACTION WITH FUROSEMIDE AND GOSSYPOL, The Journal of laboratory and clinical medicine, 132(1), 1998, pp. 32-38
Citations number
30
Categorie Soggetti
Medicine, General & Internal","Medicine, Research & Experimental","Medical Laboratory Technology
Journal title
The Journal of laboratory and clinical medicine → ACNP
ISSN journal
00222143
Volume
132
Issue
1
Year of publication
1998
Pages
32 - 38
Database
ISI
SICI code
0022-2143(1998)132:1<32:IO1DBB>2.0.ZU;2-T
Abstract
Inhibition of 11 beta-hydroxysteroid dehydrogenase (11 beta-OHSD) can cause a mineralocorticoid effect, This enzyme, in guinea pig renal cor tex microsomes in vitro, is inhibited by quercetin, tea polyphenols, f urosemide, and gossypol, The dietary polyphenols, quercetin and tea po lyphenols, interact with furosemide to enhance its 11 beta-OHSD inhibi tory effect. Tea polyphenols added to the effect of gossypol, We concl ude that the diet contains inhibitors of 11 beta-OHSD that can alter t he activity of this enzyme and may modify the degree of endogenous min eralocorticoid activity.