The nonlinear effect of gluon depletion in the collision of large nucl
ei can be large. It is due to multiple scatterings among comoving part
ons initiated by primary scattering of partons in the colliding nuclei
. The effect can give rise to substantial suppression of J/psi product
ion in very large nuclei, even if the linear depletion effect is insig
nificant for the collisions of nuclei of smaller sizes. This mechanism
offers a natural explanation of the enhanced suppression in the Pb-Pb
data recently observed by NA50.