PRODUCTION OF ANTIBIOTICS BY COLLYBIA-NIVALIS, OMPHALOTUS-OLEARIUS, AFAVOLASCHIA AND A PTERULA SPECIES ON NATURAL SUBSTRATES

Collybia nivalis, Favolaschia sp. 87129, Pterula sp. 82168 and Omphalo tus olearius were cultivated on natural substrates. The antibiotic met abolites oudemansin A, strobilurins A, D, illudin S and pterulone were isolated and identified. A new antifungal metabolite, pterulone B, wa s described from cultures of Pterula sp. 82168 on wood. Collybia nival is was found to be the first species of this genus to produce strobilu rins and oudemansin A. As compared to rich media the cultivation on na tural substrates resulted in the production of fewer metabolites. The concentrations of the antibiotics, however, were sufficient to inhibit other saprophytic fungi.