ESSENTIAL CYS-PRO-CYS MOTIF OF CAENORHABDITIS-ELEGANS COPPER TRANSPORT ATPASE

Authors
YOSHIMIZU T OMOTE H WAKABAYASHI T SAMBONGI Y FUTAI M
Citation
T. Yoshimizu et al., ESSENTIAL CYS-PRO-CYS MOTIF OF CAENORHABDITIS-ELEGANS COPPER TRANSPORT ATPASE, Bioscience, biotechnology, and biochemistry, 62(6), 1998, pp. 1258-1260
Citations number
14
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
62
Issue
6
Year of publication
1998
Pages
1258 - 1260
Database
ISI
SICI code
0916-8451(1998)62:6<1258:ECMOCC>2.0.ZU;2-G
Abstract
Caenorhabditis elegans putative copper ATPase (CUA-1) had been functio nally expressed in a yeast Delta ccc2 mutant (copper ATPase gene disru ptant), We found that CUA-1 with Cys-Pro-Cys to Cys-Pro-Ala mutation c ould not rescue the yeast Delta ccc2 mutant, suggesting that the carbo xyl terminal cysteine residue in the conserved Cys-Pro-Cys motif is es sential for copper transport.