ALL-TRANS-RETINOIC ACID AS THE POSSIBLE CAUSE OF NECROTIZING VASCULITIS

All trans retinoic acid (ATRA) is the drug of choice in the treatment of acute promyelocytic leukemia (APL). Generally, it is well tolerated but it has some side-effects, some of which may be fatal. The most se vere side-effect of ATRA is ATRA syndrome; the other side-effects are rather dermatologic. Among these vasculitis has not been reported so f ar. We detected fever and skin lesions in two patients treated with AT RA where histopathologic examination revealed necrotizing vasculitis. With cessation of ATRA. and corticosteroid administration, the lesions healed and fever quickly disappeared. (C) 1998 Elsevier Science Ltd. All rights reserved.