Di. Watson et al., EFFICACY OF ANTERIOR, POSTERIOR AND TOTAL FUNDOPLICATION IN AN EXPERIMENTAL-MODEL, British Journal of Surgery, 85(7), 1998, pp. 1006-1009
Background This study examined the effect of different types of laparo
scopic fundoplication on an incompetent lower oesophageal sphincter to
test their effectiveness at preventing gastrooesophageal reflux in th
e early postoperative period. Methods An experimental porcine model wa
s used. Initial oesophageal myotomy ensured an incompetent lower oesop
hageal sphincter with free reflux of 'intragastric fluid'. Anterior, p
osterior or total fundoplication was then performed laparoscopically i
n 15 laboratory pigs (five in each group). Fundoplication competence a
nd efficacy were determined 2 weeks after laparoscopic antireflux surg
ery by inflating the stomach with liquid through a gastrostomy cannula
. Some animals were also studied at 4 and 6 weeks. Lower oesophageal s
phincter pressure was determined using a water-perfused oesophageal ma
nometry catheter incorporating a Dent sleeve. Results All three types
of fundoplication produced similar increases in postoperative resting
lower oesophageal sphincter pressure and restored adequate competence
to the gastro-oesophageal junction. Conclusion All three variants of l
aparoscopic fundoplication restore gastro-oesophageal competence in th
e early postoperative period.