EARLY DEVELOPMENTAL TRAJECTORIES OF MALES WITH FRAGILE-X-SYNDROME

Findings from a prospective longitudinal study of 46 boys with fragile X syndrome between the ages of 24 and 72 months were reported. Hierar chical linear modeling was used to construct and evaluate overall deve lopmental trajectories and scores in five domains: Cognition, Communic ation, Adaptive, Motor, and Personal-Social, The children varied widel y, with significant differences across individuals in both mean rate a nd level of performance. Overall development was significantly delayed , with a slope of .48-approximately half the rate expected for typical ly developing children. No differences were found in rates of growth a cross the five domains. Significant differences were found, however, i n mean levels of performance. At every age tested, Motor and Adaptive scores were higher than Communication and Cognitive.