CAN A DIAGNOSIS OF RENAL-ALLOGRAFT REJECTION BE BASED ON HISTOLOGY ALONE

Acute renal allograft rejection is suspected by the clinician when the serum creatinine value increases in a patient for no other particular cause. A renal allograft biopsy may confirm the diagnosis. This repor t describes 2 patients with stable serum creatinine; however, protocol biopsy showed acute rejection changes according to the Banff criteria . No anti-rejection treatment was started and their graft function rem ained stable for 6 months. These two cases focus on the fact that rena l allograft rejection should first of all be regarded as a clinical di agnosis which could be substantiated by histological findings.