We describe a connection between the Picard group of a ring with local
units T and the Picard group of the unital overring End(T-T). Using t
his connection, we show that the three groups Pic(R), Pic(FM(R)), and
Pic(RFM(R)) are isomorphic for any unital ring R. Furthermore, each el
ement of Pic(RFM(R)) arises from an automorphism of RFM(R), which yiel
ds an isomorphsm between Pic(RFM(R)) and Out(RFM(R)). As one applicati
on we extend a classical result of Rosenberg and Zelinsky by showing t
hat the group Out(R)(RFM(R)) is abelian for any commutative unital rin
g R.