PHARMACOLOGICAL STIMULATION OF ARTERIAL CHEMORECEPTORS IN CONSCIOUS RATS PRODUCES DIFFERENTIAL RESPONSES IN RENAL CORTICAL AND MEDULLARY BLOOD-FLOW

1, There have been no previously published data regarding intrarenal b lood flow distribution in acute whole-body hypoxic hypoxia and/or arte rial chemoreceptor stimulation in normoxic mammals. 2, Cortical and me dullary blood flows were measured simultaneously before and in respons e to pharmacological stimulation of peripheral arterial chemoreceptors by i,v, injection of almitrine bismesylate (0.25 mg/kg). 3, Arterial chemoreceptor excitation reduced cortical blood dow but only in innerv ated kidneys, An effect on medullary blood flow was observed in neithe r innervated nor denervated kidneys. 4, These data indicate that renal cortical and medullary blood hows react differently to arterial chemo receptor stimulation.