ACTIVATION OF C-JUN AND C-FOS GENES IN DNTP IMBALANCE CELL-DEATH INDUCED WITH 5-FLUORO-2'-DEOXYURIDINE IN MOUSE MAMMARY-TUMOR FM3A CELL-LINE

5-Fluoro-2'-deoxyuridine (FdUrd)-induced death of mouse mammary FM3A c ells was found to be associated with an increased expression of cellul ar c-jun and c-fos genes. The increase in these gene expressions was m ediated through the protein kinase C-dependent pathway. Blockage of th e expression with the use of antisense oligodeoxynucleotide for c-jun delayed the cell death. These findings suggest that the activation of c-jun and c-fos genes, which encode transcription factors participatin g in cell proliferation, plays a role in FdUrd-induced cell death.